Fructose Intolerance and Hypoglucosemia in the Newborn Fructose Tolerance
نویسندگان
چکیده
The normal newborn infant has inadequate homeostatic mechanisms for stabilizing the concentration of glucose in the blood (1, 2). Recent studies of carbohydrate metabolism in this age group have indicated a diminished responsiveness to small doses (30 jug per kg body weight) of exogenous glucagon (3, 4) and a slow rate of disappearance from the blood of either glucose or galactose administered intravenously (4, 5). Similar results have been observed in the premature infant (6). Glucose uptake by the tissues improves with a second dose and with age. The newborn infant is sensitive to exogenous insulin (5, 6), and insulin-like substances have been found in umbilical vein blood (7). We interpret the effects of the injection of either glucagon or galactose, which resulted in a prompt rise in the concentration of glucose in the blood, to indicate functional adequacy of the enzymes of the glycogen cycle in the liver of the newborn infant. Since the pathway for fructose metabolism in the liver differs from that of galactose or glucose, we wished to evaluate the effect of a rapid infusion of fructose on the concentration of glucose and lactate in the blood of newborn infants. The possible mechanisms involved are elucidated by combining the effects of epinephrine plus glucagon or galactose and fructose infusions.
منابع مشابه
An experimental renal acidification defect in patients with hereditary fructose intolerance. I. Its resemblance to renal tubular acidosis.
In three unrelated patients with hereditary fructose intolerance (HFI), but in none of five normal subjects, the experimental administration of fructose invariably induced a reversible dysfunction of the renal tubule with biochemical and physiological characteristics of renal tubular acidosis. During a state of ammonium chloride-induced acidosis, (a) urinary pH was greater than six and the rate...
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